• PRMT1 Monoclonal Antibody
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Upingbio

YP-Ab-03442-100UL

PRMT1 Monoclonal Antibody

PRMT1 Monoclonal Antibody

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  • Reaction species: Human;Mouse;Rat;Dog;Rabbit
  • Gene Name: PRMT1
  • Protein name: Protein arginine N-methyltransferase 1
  • Immunogen: Purified recombinant human PRMT1 protein fragments expressed in E.coli.
  • Specificity: PRMT1 Monoclonal Antibody detects endogenous levels of PRMT1 protein.
  • Composition: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
  • Source: Monoclonal, Mouse
  • Dilution ratio: Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.
  • Purification process: Affinity purification
  • Concentration: mg/ml
  • Storage: -20°C/1 year
  • Other Names: PRMT1; HMT2; HRMT1L2; IR1B4; Protein arginine N-methyltransferase 1; Histone-arginine N-methyltransferase PRMT1; Interferon receptor 1-bound protein 4
  • Background: This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011],
  • Function: enzyme regulation:By BTG1, BTG2 and ILF3.,function:Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain (may methylate HNRNPA1 and histones). Methylates SUPT5H and EWS.,similarity:Belongs to the protein arginine N-methyltransferase family.,subunit:Homodimer and heterodimer with PRMT8. The dimer can then associate to form a homohexamer. Interacts with ILF3, BTG1, BTG2, SUPT5H and interferon-alpha/beta receptor 1. Interacts with NFATC2IP.,
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