• Arrestin-β-2 Monoclonal Antibody
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Upingbio

YP-Ab-03432-10UL

Arrestin-β-2 Monoclonal Antibody

Arrestin-β-2 Monoclonal Antibody

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  • Reaction species: Human;Mouse;Rat;Pig
  • Gene Name: ARRB2
  • Protein name: Beta-arrestin-2
  • Molecular weight (DA): 46kD
  • Immunogen: Purified recombinant human Arrestin-β-2 (C-terminus) protein fragments expressed in E.coli.
  • Specificity: Arrestin-β-2 Monoclonal Antibody detects endogenous levels of Arrestin-β-2 protein.
  • Composition: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
  • Source: Monoclonal, Mouse
  • Dilution ratio: Western Blot: 1/1000 - 1/2000. Immunofluorescence: 1/100 - 1/500. Not yet tested in other applications.
  • Purification process: Affinity purification
  • Concentration: mg/ml
  • Storage: -20°C/1 year
  • Other Names: ARRB2; ARB2; ARR2; Beta-arrestin-2; Arrestin beta-2
  • Background: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012],
  • Function: function:Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.,online information:Arrestin entry,similarity:Belongs to the arrestin family.,
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