• ADAMTS-17 Polyclonal Antibody
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Upingbio

YP-Ab-02481-100UL

ADAMTS-17 Polyclonal Antibody

ADAMTS-17 Polyclonal Antibody

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  • Gene Name: ADAMTS17
  • Immunogen: Synthesized peptide derived from ADAMTS-17 . at AA range: 150-230
  • Specificity: ADAMTS-17 Polyclonal Antibody detects endogenous levels of ADAMTS-17 protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: ADAMTS17; A disintegrin and metalloproteinase with thrombospondin motifs 17; ADAM-TS 17; ADAM-TS17; ADAMTS-17
  • Background: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may promote breast cancer cell growth and survival. Mutations in this gene are associated with a Weill-Marchesani-like syndrome, which is characterized by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. [provided by RefSeq, May 2016],
  • Function: domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 5 TSP type-1 domains.,tissue specificity:Expressed in fetal lung, in adult brain, prostate, and liver.,
  • Species: Human;Mouse
  • Range: IHC;IF;ELISA
  • Protein: A disintegrin and metalloproteinase with thrombospondin motifs 17
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