• CYP7A1 Monoclonal Antibody
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Upingbio

YP-Ab-02349-53UL

CYP7A1 Monoclonal Antibody

CYP7A1 Monoclonal Antibody

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  • Reaction species: Human;Golden hamster
  • Gene Name: CYP7A1
  • Protein name: Cholesterol 7-alpha-monooxygenase
  • Molecular weight (DA): 58kD
  • Immunogen: Purified recombinant human CYP7A1 (C-terminus) protein fragments expressed in E.coli.
  • Specificity: CYP7A1 Monoclonal Antibody detects endogenous levels of CYP7A1 protein.
  • Composition: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
  • Source: Monoclonal, Mouse
  • Dilution ratio: Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.
  • Purification process: Affinity purification
  • Concentration: mg/ml
  • Storage: -20°C/1 year
  • Other Names: CYP7A1; CYP7; Cholesterol 7-alpha-monooxygenase; CYPVII; Cholesterol 7-alpha-hydroxylase; Cytochrome P450 7A1
  • Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010],
  • Function: catalytic activity:Cholesterol + NADPH + O(2) = 7-alpha-hydroxycholesterol + NADP(+) + H(2)O.,cofactor:Heme group.,online information:Cholesterol-7 alpha-hydroxylase entry,pathway:Lipid metabolism; bile acid biosynthesis.,similarity:Belongs to the cytochrome P450 family.,
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