• Cleaved-SUMO-2/3 (G93) Polyclonal Antibody
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Upingbio

YP-Ab-02298-100UL

Cleaved-SUMO-2/3 (G93) Polyclonal Antibody

Cleaved-SUMO-2/3 (G93) Polyclonal Antibody

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  • Gene Name: SUMO2 SUMO3
  • Immunogen: The antiserum was produced against synthesized peptide derived from human SUMO2/3. AA range:44-93
  • Specificity: Cleaved-SUMO-2/3 (G93) Polyclonal Antibody detects endogenous levels of fragment of activated SUMO-2/3 protein resulting from cleavage adjacent to G93.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. IP 1:50-100 Not yet tested in other applications.
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: SUMO2; SMT3A; SMT3H2; Small ubiquitin-related modifier 2; SUMO-2; HSMT3; SMT3 homolog 2; SUMO-3; Sentrin-2; Ubiquitin-like protein SMT3A; Smt3A
  • Background: This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
  • Function: function:Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.,online information:SUMO protein entry,PTM:Cleavage of precursor form by SENP1 or SENP2 is necessary for function.,PTM:Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.,PTM:Polymeric chains can be formed through Lys-11 cross-linking.,similarity:Belongs to the ubiquitin family. S
  • Species: Human;Mouse;Rat
  • Range: WB;ELISA;CoIP
  • Protein: Small ubiquitin-related modifier 2
  • DA: 11kD
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