• Topo IIIα Polyclonal Antibody
1 1

Upingbio

YP-Ab-02256-100UL

Topo IIIα Polyclonal Antibody

Topo IIIα Polyclonal Antibody

$0.00 USD
$0.00 USD
Sale Sold out
Shipping calculated at checkout.
Size
  • Gene Name: TOP3A
  • Immunogen: Synthesized peptide derived from Topo IIIα . at AA range: 350-430
  • Specificity: Topo IIIα Polyclonal Antibody detects endogenous levels of Topo IIIα protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: TOP3A; TOP3; DNA topoisomerase 3-alpha; DNA topoisomerase III alpha
  • Background: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016],
  • Function: catalytic activity:ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.,function:Reduces the number of supercoils in a highly negatively supercoiled DNA. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells.,similarity:Belongs to the prokaryotic type I/III topoisomerase family.,subunit:Directly interacts with BLM and RMI1. Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM.,tissue specificity:High expression is found in testis, heart, skeletal muscle and pancreas.,
  • Species: Human;Mouse
  • Range: WB;ELISA
  • Protein: DNA topoisomerase 3-alpha
  • DA: 115kD
View full details