• NXF3 Polyclonal Antibody
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Upingbio

YP-Ab-01924-100UL

NXF3 Polyclonal Antibody

NXF3 Polyclonal Antibody

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  • Gene Name: NXF3
  • Immunogen: The antiserum was produced against synthesized peptide derived from human NXF3. AA range:72-121
  • Specificity: NXF3 Polyclonal Antibody detects endogenous levels of NXF3 protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: NXF3; TAPL3; Nuclear RNA export factor 3; TAP-like protein 3; TAPL-3
  • Background: This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008],
  • Function: domain:Contains a novel CRM1-dependent nuclear export signal that compensates in cis for the loss of the nuclear pore targeting domain.,domain:Lacks C-terminal domain that mediates direct interactions with nucleoporins.,function:May function as a tissue-specific nuclear mRNA export factor.,miscellaneous:The RNA-binding domain is a non-canonical RNP-type domain.,similarity:Belongs to the NXF family.,similarity:Contains 1 LRR (leucine-rich) repeat.,similarity:Contains 1 NTF2 domain.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subcellular location:Shuttles between the nucleus and the cytoplasm.,subunit:Interacts with NXT1, NXT2, E1B-AP5 and CRM1 nuclear export factor.,tissue specificity:Expressed at high level in testis and at low level in a small number of tissues.,
  • Species: Human;Rat;Mouse;
  • Range: WB;IHC;IF;ELISA
  • Protein: Nuclear RNA export factor 3
  • DA: 60kD
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