• KLF8 Polyclonal Antibody
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Upingbio

YP-Ab-01840-100UL

KLF8 Polyclonal Antibody

KLF8 Polyclonal Antibody

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  • Gene Name: KLF8
  • Immunogen: The antiserum was produced against synthesized peptide derived from human KLF8. AA range:191-240
  • Specificity: KLF8 Polyclonal Antibody detects endogenous levels of KLF8 protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: KLF8; BKLF3; ZNF741; Krueppel-like factor 8; Basic krueppel-like factor 3; Zinc finger protein 741
  • Background: This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009],
  • Function: function:Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).,PTM:Sumoylation at Lys-67 represses transcriptional activity and reduces cell cycle progression into the G(1) phase. Has no effect on subcellular location.,similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,subunit:Interacts with corepressor CtBP2. Interacts with PIAS1, PIAS2, AND PIAS4; the interaction with each ligase sumoylates KLF8.,tissue specificity:Ubiquitous.,
  • Species: Human;Rat;Mouse;
  • Range: IHC;IF;ELISA
  • Protein: Krueppel-like factor 8
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