• Hexim1 Polyclonal Antibody
1 1

Upingbio

YP-Ab-01774-100UL

Hexim1 Polyclonal Antibody

Hexim1 Polyclonal Antibody

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  • Gene Name: HEXIM1
  • Immunogen: The antiserum was produced against synthesized peptide derived from human HEXIM1. AA range:181-230
  • Specificity: Hexim1 Polyclonal Antibody detects endogenous levels of Hexim1 protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: HEXIM1; CLP1; EDG1; HIS1; MAQ1; Protein HEXIM1; Cardiac lineage protein 1; Estrogen down-regulated gene 1 protein; Hexamethylene bis-acetamide-inducible protein 1; Menage a quatre protein 1
  • Background: Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008],
  • Function: domain:The coiled-coil domain mediates oligomerization.,function:Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.,induction:Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level). Down-regulated by estrogen.,miscellaneous:Inhibits Tat activity which is required for HIV-1 transcription.,similarity:Belongs to the HEXIM family.,subcellular location:Binds alpha-importin and is mostly nuclear.,subunit:Homooligomer and heterooligomer with HEXIM2; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, H
  • Species: Human;Mouse;Rat
  • Range: WB;IHC;IF;ELISA
  • Protein: Protein HEXIM1
  • DA: 40kD
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