• Eme1 Polyclonal Antibody
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Upingbio

YP-Ab-01694-100UL

Eme1 Polyclonal Antibody

Eme1 Polyclonal Antibody

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  • Gene Name: EME1
  • Immunogen: Synthesized peptide derived from Eme1 . at AA range: 250-330
  • Specificity: Eme1 Polyclonal Antibody detects endogenous levels of Eme1 protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: EME1; MMS4; Crossover junction endonuclease EME1; MMS4 homolog; hMMS4
  • Background: This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009],
  • Function: cofactor:Magnesium.,function:Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.,similarity:Belongs to the EME1/MMS4 family.,subcellular location:Recruited to regions of DNA damage in S-phase cells.,subunit:May self-associate. Interacts with MUS81. Interacts with ERCC4 and FANCM.,
  • Species: Human;Rat;Mouse;
  • Range: WB;ELISA
  • Protein: Crossover junction endonuclease EME1
  • DA: 65kD
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