• DNA pol ε 4 Polyclonal Antibody
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Upingbio

YP-Ab-01659-100UL

DNA pol ε 4 Polyclonal Antibody

DNA pol ε 4 Polyclonal Antibody

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  • Gene Name: POLE4
  • Immunogen: The antiserum was produced against synthesized peptide derived from human POLE4. AA range:61-110
  • Specificity: DNA pol ε 4 Polyclonal Antibody detects endogenous levels of DNA pol ε 4 protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: POLE4; DNA polymerase epsilon subunit 4; DNA polymerase II subunit 4; DNA polymerase epsilon subunit p12
  • Background: POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004],
  • Function: catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,function:May play a role in allowing polymerase epsilon to carry out its replication and/or repair function.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subunit:Consists of four subunits: POLE1, POLE2, POLE3 and POLE4. Interacts with POLE3. When bound to POLE3, it can associate with polymerase epsilon p261 and p59 and form a complex.,
  • Species: Human;Mouse
  • Range: IHC;IF;ELISA
  • Protein: DNA polymerase epsilon subunit 4
  • DA: 12kD
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