• APOBEC3A Polyclonal Antibody
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Upingbio

YP-Ab-01534-100UL

APOBEC3A Polyclonal Antibody

APOBEC3A Polyclonal Antibody

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  • Gene Name: APOBEC3A
  • Immunogen: The antiserum was produced against synthesized peptide derived from human APOBEC3A. AA range:27-76
  • Specificity: APOBEC3A Polyclonal Antibody detects endogenous levels of APOBEC3A protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: APOBEC3A; Probable DNA dC->dU-editing enzyme APOBEC-3A; Phorbolin-1
  • Background: This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided b
  • Function: cofactor:Zinc.,function:Lacks cytidine deaminase activity, at least on RNA molecules (monomeric nucleoside substrates or synthetic apoB RNA template). Unable to reduce HIV-1 infectivity in vitro.,miscellaneous:It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.,similarity:Belongs to the cytidine and deoxycytidylate deaminase family.,tissue specificity:Expressed in peripherical leukocytes and keratinocytes.,
  • Species: Human;Rat;Mouse;
  • Range: WB;ELISA
  • Protein: Probable DNA dC->dU-editing enzyme APOBEC-3A
  • DA: 26kD
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