• CALHM1 Polyclonal Antibody
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Upingbio

YP-Ab-01215-100UL

CALHM1 Polyclonal Antibody

CALHM1 Polyclonal Antibody

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  • Gene Name: CALHM1
  • Immunogen: Synthetic Peptide of CALHM1 AA range: 204-254
  • Specificity: The antibody detects endogenous CALHM1 protein.
  • Composition: PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB: 1:500-1000 IHC: 1:200-500. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Storage: -20°C/1 year
  • Other Names: Calcium homeostasis modulator protein 1; Protein FAM26C
  • Background: calcium homeostasis modulator 1(CALHM1) Homo sapiens This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010],
  • Function: function:May be a pore-forming ion channel. Controls cytosolic Ca(2+) permeability and cytosolic Ca(2+) concentration. Controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner.,polymorphism:Leu-86 causes a dysregulation of Ca(2+) homeostasis and amyloid precursor protein (APP) metabolism, and may be a risk factor for the development of Alzheimer's disease.,similarity:Belongs to the FAM26 family.,subcellular location:Colocalizes with HSPA5 at the endoplasmic reticulum.,subunit:Homooligomer; homomultimerized to form dimeric and possibly tetrameric structures.,tissue specificity:Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells.,
  • Species: Human;Rat
  • Range: WB;IHC;IF
  • Protein: Calcium homeostasis modulator protein 1
  • DA: 40kD
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