• Acetyl-Histone H3 (K9) Monoclonal Antibody(2E7)
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Upingbio

YP-Ab-01172-53UL

Acetyl-Histone H3 (K9) Monoclonal Antibody(2E7)

Acetyl-Histone H3 (K9) Monoclonal Antibody(2E7)

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  • Reaction species: Human;Rat;Mouse
  • Gene Name: HIST1H3A
  • Protein name: HIST1H3A
  • Molecular weight (DA): 15kD
  • Immunogen: Synthetic Peptide of Acetyl-Histone H3 (K9)
  • Specificity: Acetyl-Histone H3 (K9) Monoclonal Antibody(2E7) detects endogenous levels of HIST1H3A
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Monoclonal, Mouse
  • Dilution ratio: IHC-p 1:50-300,WB 1:500-2000. IF 1:50-200
  • Purification process: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • Concentration: mg/ml
  • Storage: -20°C/1 year
  • Other Names: HIST1H3A;H3k9AC
  • Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015],
  • Function: caution:Was originally (PubMed:2587222) thought to originate from mouse.,developmental stage:Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.,function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,mass spectrometry:Monoisotopic with N-acetylserine PubMed:16457589,miscellaneous:This histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation of Lys-10 (H3K9me2).,PTM:Acetylation is generally l
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