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Upingbio
SKU:YP-Ab-01043-53UL
Ikaros Monoclonal Antibody
Ikaros Monoclonal Antibody
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- Reaction species: Human;Mouse;Dog
- Gene Name: IKZF1
- Protein name: DNA-binding protein Ikaros
- Immunogen: Purified recombinant human Ikaros (C-terminus) protein fragments expressed in E.coli.
- Specificity: Ikaros Monoclonal Antibody detects endogenous levels of Ikaros protein.
- Composition: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
- Source: Monoclonal, Mouse
- Dilution ratio: Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.
- Purification process: Affinity purification
- Concentration: mg/ml
- Storage: -20°C/1 year
- Other Names: IKZF1; IK1; IKAROS; LYF1; ZNFN1A1; DNA-binding protein Ikaros; Ikaros family zinc finger protein 1; Lymphoid transcription factor LyF-1
- Background: This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding
- Function: function:Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Functions in the specification and the maturation of the T-lymphocyte. Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development.,similarity:Belongs to the Ikaros C2H2-type zinc-finger protein family.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with IKZF4 AND IKZF5.,tissue specificity:Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine.,
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