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Upingbio
SKU:YP-Ab-00999-10UL
LysRS Monoclonal Antibody
LysRS Monoclonal Antibody
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- Reaction species: Human
- Gene Name: KARS
- Protein name: Lysyl-tRNA synthetase
- Immunogen: Purified recombinant fragment of LysRS(aa90-174) expressed in E. Coli.
- Specificity: LysRS Monoclonal Antibody detects endogenous levels of LysRS protein.
- Composition: Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
- Source: Monoclonal, Mouse
- Dilution ratio: WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. ELISA: 1/10000.. IF 1:50-200
- Purification process: Affinity purification
- Storage: -20°C/1 year
- Other Names: KARS; KIAA0070; Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS
- Background: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
- Function: catalytic activity:ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).,similarity:Belongs to the class-II aminoacyl-tRNA synthetase family.,subunit:Homodimer (By similarity); also part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro.,
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