• Islet-1 Monoclonal Antibody
1 1

Upingbio

YP-Ab-00993-10UL

Islet-1 Monoclonal Antibody

Islet-1 Monoclonal Antibody

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  • Reaction species: Human
  • Gene Name: ISL1
  • Protein name: Insulin gene enhancer protein ISL-1
  • Immunogen: Purified recombinant fragment of human Islet-1 expressed in E. Coli.
  • Specificity: Islet-1 Monoclonal Antibody detects endogenous levels of Islet-1 protein.
  • Composition: Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
  • Source: Monoclonal, Mouse
  • Dilution ratio: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
  • Purification process: Affinity purification
  • Storage: -20°C/1 year
  • Other Names: ISL1; Insulin gene enhancer protein ISL-1; Islet-1
  • Background: This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008],
  • Function: function:Binds to one of the cis-acting domain of the insulin gene enhancer.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 2 LIM zinc-binding domains.,tissue specificity:Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.,
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