• FoxO4 (Acetyl Lys189) Polyclonal Antibody
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Upingbio

YP-Ab-00872-100UL

FoxO4 (Acetyl Lys189) Polyclonal Antibody

FoxO4 (Acetyl Lys189) Polyclonal Antibody

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  • Gene Name: FOXO4 AFX AFX1 MLLT7
  • Immunogen: Synthetic Acetyl peptide from human protein at AA range: 189
  • Specificity: The antibody detects endogenous FoxO4 when Acetyl occurs at Lys189
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000, ELISA 1:10000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: Forkhead box protein O4 (Fork head domain transcription factor AFX1)
  • Background: This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010],
  • Function: disease:A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X;11)(q13;q23) with MLL/HRX. The result is a rogue activator protein.,function:Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.,pharmaceutical:A constitutively active FOXO4 mutant where phosphorylation sites Thr-32, Ser-187 and Ser-262 have been mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival, transformation and tumorigenicity.,PTM:Acetylation by CBP, which is induced by peroxidase stress, inhibits transcriptional activity. Dea
  • Species: Human;Rat;Mouse;
  • Range: WB;ELISA
  • Protein: Forkhead box protein O4 (Fork head domain transcription factor AFX1)
  • DA: 55kD
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