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Upingbio
SKU:YP-Ab-00620-53UL
Nup98 Monoclonal Antibody
Nup98 Monoclonal Antibody
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- Reaction species: Human;Mouse;Dog
- Gene Name: NUP98
- Protein name: Nuclear pore complex protein Nup98-Nup96
- Immunogen: Purified recombinant human Nup98 protein fragments expressed in E.coli.
- Specificity: Nup98 Monoclonal Antibody detects endogenous levels of Nup98 protein.
- Composition: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
- Source: Monoclonal, Mouse
- Dilution ratio: Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.
- Purification process: Affinity purification
- Concentration: mg/ml
- Storage: -20°C/1 year
- Other Names: NUP98; ADAR2; Nuclear pore complex protein Nup98-Nup96
- Background: Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of
- Function: disease:A chromosomal aberration involving NUP98 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with PSIP1/LEDGF. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.,disease:A chromosomal aberration involving NUP98 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with HOXA9. Translocation t(11;17)(p15;p13) with PHF23.,disease:A chromosomal aberration involving NUP98 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(3;11)(q12.2;p15.4) with LNP1.,disease:A chromosomal aberration involving NUP98 is found in a form of therapy-related myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with TOP1.,disease:A chromosomal aberration involving NUP98 is found in childhood
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