• TACC1 Polyclonal Antibody
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Upingbio

YP-Ab-00527-100UL

TACC1 Polyclonal Antibody

TACC1 Polyclonal Antibody

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  • Gene Name: TACC1
  • Immunogen: The antiserum was produced against synthesized peptide derived from human TACC1. AA range:11-60
  • Specificity: TACC1 Polyclonal Antibody detects endogenous levels of TACC1 protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: TACC1; KIAA1103; Transforming acidic coiled-coil-containing protein 1; Gastric cancer antigen Ga55; Taxin-1
  • Background: This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009],
  • Function: alternative products:Additional isoforms seem to exist,developmental stage:Expressed at high level during early embryogenesis.,function:Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.,miscellaneous:Down-regulated in a subset of cases of breast cancer.,PTM:Isoform 1 is heavily phosphorylated; isoform 6 is not. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the TACC family.,similarity:Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains.,subcellular location:Nucleus during interphase. Weakly concentrated at centrosomes during mitosis.,subunit:Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with the Aurora kinases A and B (STK6 and AURKB). Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF.,tissue specificity:Isoform 1, isoform 3 and isoform 5 a
  • Species: Human;Mouse
  • Range: WB;IHC;IF;ELISA
  • Protein: Transforming acidic coiled-coil-containing protein 1
  • DA: 87kD
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