• PRP19 Polyclonal Antibody
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Upingbio

YP-Ab-00501-100UL

PRP19 Polyclonal Antibody

PRP19 Polyclonal Antibody

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  • Gene Name: PRPF19
  • Immunogen: The antiserum was produced against synthesized peptide derived from human PRPF19. AA range:171-220
  • Specificity: PRP19 Polyclonal Antibody detects endogenous levels of PRP19 protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: PRPF19; NMP200; PRP19; SNEV; Pre-mRNA-processing factor 19; Nuclear matrix protein 200; PRP19/PSO4 homolog; hPso4; Senescence evasion factor
  • Background: PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008 [PubMed 18263876]).[supplied by OMIM, Sep 2008],
  • Function: function:Plays a role in DNA double-strand break (DSB) repair and pre-mRNA splicing reaction. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Overexpression of PRPF19 might extend the cellular life span by increasing the resistance to stress or by improving the DNA repair capacity of the cells.,induction:By gamma radiation and chemical mutagens but not by UV treatment.,similarity:Belongs to the WD repeat PRP19 family.,similarity:Contains 1 U-box domain.,similarity:Contains 7 WD repeats.,subcellular locatio
  • Species: Human;Mouse;Rat
  • Range: WB;IHC;IF;ELISA
  • Protein: Pre-mRNA-processing factor 19
  • DA: 50kD
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