• PARP-4 Polyclonal Antibody
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Upingbio

YP-Ab-00485-100UL

PARP-4 Polyclonal Antibody

PARP-4 Polyclonal Antibody

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  • Gene Name: PARP4
  • Immunogen: The antiserum was produced against synthesized peptide derived from human PARP4. AA range:1151-1200
  • Specificity: PARP-4 Polyclonal Antibody detects endogenous levels of PARP-4 protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: PARP4; ADPRTL1; KIAA0177; PARPL; Poly [ADP-ribose] polymerase 4; PARP-4; 193 kDa vault protein; ADP-ribosyltransferase diphtheria toxin-like 4; ARTD4; PARP-related/IalphaI-related H5/proline-rich; PH5P; Vault poly(ADP-ribose) polymerase; VP
  • Background: This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008],
  • Function: catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 PARP alpha-helical domain.,similarity:Contains 1 PARP catalytic domain.,similarity:Contains 1 VWFA domain.,subcellular location:Also found in the nucleus, associated with mitotic spindles.,subunit:Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to MVP. Associates with TEP1.,tissue specificity:Widely expressed; the highest levels are in the kidney; also detected in heart, placenta, lung, liver, skeletal muscle, spleen, leukocytes and pancreas.,
  • Species: Human;Rat;Mouse;
  • Range: IHC;IF;ELISA
  • Protein: Poly [ADP-ribose] polymerase 4
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