• Tuberin/TSC2 (phospho-Ser664) rabbit pAb
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Upingbio

YP-Ab-00286-100UL

Tuberin/TSC2 (phospho-Ser664) rabbit pAb

Tuberin/TSC2 (phospho-Ser664) rabbit pAb

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  • Gene Name: TSC2 TSC4
  • Immunogen: Synthesized phosho peptide around human Tuberin (Ser664)
  • Specificity: This antibody detects endogenous levels of Human Tuberin/TSC2 (phospho-Ser664)
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:1000-2000
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: Tuberin (Tuberous sclerosis 2 protein)
  • Background: Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
  • Function: alternative products:Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms,disease:Defects in TSC2 are a cause of lymphangioleiomyomatosis (LAM) [MIM:606690]. LAM is a progressive and often fatal lung disease characterized by a diffuse proliferation of abnormal smooth muscle cells in the lungs. It affects almost exclusively young women and can occur as an isolated disorder or in association with tuberous sclerosis complex.,disease:Defects in TSC2 are the cause of tuberous sclerosis complex (TSC) [MIM:191100]. The molecular basis of TSC is a functional impairment of the tuberin-hamartin complex. TSC is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. TSC is characterized by hamartomas (benign overgrowths predominantly of a cell or tissue type that occurs normally in the organ) and hamartias (de
  • Species: Human;Rat;Mouse;
  • Range: WB
  • Protein: Tuberin/TSC2 (Ser664)
  • DA: 200kD
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