• PRAS40 (phospho-Ser183) rabbit pAb
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YP-Ab-00278-100UL

PRAS40 (phospho-Ser183) rabbit pAb

PRAS40 (phospho-Ser183) rabbit pAb

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  • Gene Name: AKT1S1 PRAS40
  • Immunogen: Synthesized phosho peptide around human PRAS40 (Ser183)
  • Specificity: This antibody detects endogenous levels of Human Mouse PRAS40 (phospho-Ser183)
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate)
  • Background: AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008],
  • Function: function:May play an important role in phosphatidylinositol 3-kinase (PI3K)-AKT1 survival signaling. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. Its role in survival signaling pathways may be modulated by oxidative stress. May also play a role in nerve growth factor-mediated neuroprotection.,subcellular location:Found in the cytosolic fraction of the brain.,subunit:The phosphorylated form interacts with 14-3-3.,tissue specificity:Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A549 and HeLa) than in normal cell lines (e.g. HEK293).,
  • Species: Human;Mouse
  • Range: WB;ELISA;IHC
  • Protein: PRAS40 (Ser183)
  • DA: 40kD
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