• 53BP1 (phospho-Ser1778) rabbit pAb
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Upingbio

YP-Ab-00260-100UL

53BP1 (phospho-Ser1778) rabbit pAb

53BP1 (phospho-Ser1778) rabbit pAb

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  • Gene Name: TP53BP1
  • Immunogen: Synthesized phosho peptide around human 53BP1 (Ser1778)
  • Specificity: This antibody detects endogenous levels of Human 53BP1 (phospho-Ser1778)
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:1000-2000
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: Tumor suppressor p53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)
  • Function: function:May have a role in checkpoint signaling during mitosis (By similarity). Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.,PTM:Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.,PTM:Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation.,similarity:Contains 2 BRCT domains.,subcellular location:Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand breaks.,subunit:Interacts with IFI202A (By similarity). Binds to th
  • Species: Human;Rat;Mouse;
  • Range: WB
  • Protein: 53BP1 (Ser1778)
  • DA: 213kD
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