• Beclin-1 mouse Monoclonal Antibody(5C2)
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Upingbio

YP-Ab-00126-53UL

Beclin-1 mouse Monoclonal Antibody(5C2)

Beclin-1 mouse Monoclonal Antibody(5C2)

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  • Reaction species: Human;Rat;Mouse;Bovine
  • Gene Name: BECN1
  • Protein name: BECN1
  • Molecular weight (DA): 60kD
  • Immunogen: Synthetic Peptide of Beclin-1 at AA range of 110-190
  • Specificity: Beclin-1 protein detects endogenous levels of BECN1
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Monoclonal, Mouse
  • Dilution ratio: WB 1:1000-2000, IHC 1:100-200. IF 1:50-200
  • Purification process: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • Concentration: mg/ml
  • Storage: -20°C/1 year
  • Other Names: BECN1
  • Background: beclin 1(BECN1) Homo sapiens This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
  • Function: function:Plays a central role in autophagy (By similarity). May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.,similarity:Belongs to the beclin family.,subcellular location:Expressed in dendrites and cell bodies of cerebellar Purkinje cells.,subunit:Interacts with GOPC and GRID2. Interacts with AMBRA1. Probably forms a complex with AMBRA1 and PIK3C3 (By similarity). Interacts with BCL2 and BCL2L1.,tissue specificity:Ubiquitous.,
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