YES1 Antibody

Size

100ug

Clone Number

Aliases

c Yes antibody; Cellular Yes 1 protein antibody; Cellular Yes1 protein antibody; HsT441 antibody; P61 YES antibody; p61-Yes antibody; Proto oncogene tyrosine protein kinase YES antibody; Proto-oncogene c-Yes antibody; Tyrosine-protein kinase Yes antibody; v yes 1 Yamaguchi sarcoma viral oncogene homolog 1 antibody; Viral oncogene yes 1 homolog 1 antibody; Viral oncogene yes1 homolog 1 antibody; Yamaguchi sarcoma oncogene antibody; Yes 1 antibody; Yes antibody; YES proto oncogene 1, Src family tyrosine kinase antibody; YES_HUMAN antibody; YES1 antibody; YES1 proto oncogene, Src family tyrosine kinase antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P07947

Immunogen

Recombinant Human Tyrosine-protein kinase Yes protein (1-155AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background

Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

YES1

Research Areas

Epigenetics and Nuclear Signaling; Cancer; Signal transduction