XRCC4 Antibody

Size

100ul

Clone Number

Aliases

DNA double strand break repair and V(D)J recombination protein XRCC4 antibody; DNA repair protein XRCC4 antibody; SSMED antibody; X ray repair complementing defective repair in Chinese hamster cells 4 antibody; X ray repair cross complementing 4 antibody; X ray repair cross complementing protein 4 antibody; X-ray repair cross-complementing protein 4 antibody; XRCC 4 antibody; XRCC4 antibody; XRCC4_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q13426

Immunogen

Recombinant Human DNA repair protein XRCC4 protein (1-336AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

XRCC4

Research Areas

Epigenetics and Nuclear Signaling