WWP2 Antibody, HRP conjugated

Size

100ug

Clone Number

Aliases

WWP2NEDD4-like E3 ubiquitin-protein ligase WWP2 antibody; EC 2.3.2.26 antibody; Atrophin-1-interacting protein 2 antibody; AIP2 antibody; HECT-type E3 ubiquitin transferase WWP2 antibody; WW domain-containing protein 2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O00308

Immunogen

Recombinant Human NEDD4-like E3 ubiquitin-protein ligase WWP2 protein (145-367AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by \\\'Lys-63\\\'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

HRP

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

WWP2

Research Areas

Epigenetics and Nuclear Signaling; Cell biology