Wnt-1 Polyclonal Antibody

Ab type

Primary antibody

Background

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. Proto-oncogene Wnt-1 have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. WNT1 is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.

Reactivity

Human;Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human WNT1. AA range:301-350

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

40982

synonyms

WNT1; INT1; Proto-oncogene Wnt-1; Proto-oncogene Int-1 homolog