WNK3 Antibody

Size

100ug

Clone Number

Aliases

KIAA1566 antibody; PRKWNK 3 antibody; PRKWNK3 antibody; Protein kinase lysine deficient 3 antibody; Protein kinase lysine-deficient 3 antibody; Protein kinase with no lysine 3 antibody; Serine/threonine protein kinase WNK3 antibody; Serine/threonine-protein kinase WNK3 antibody; WNK 3 antibody; WNK lysine deficient protein kinase 3 antibody; Wnk3 antibody; WNK3_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9BYP7

Immunogen

Recombinant Human Serine/threonine-protein kinase WNK3 protein (1018-1181AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IF; Recommended dilution: IF:1:50-1:200

Background

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:16275913, PubMed:16275911, PubMed:16357011). Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

WNK3

Research Areas

Signal transduction