WNK1 Antibody

Size

100ug

Clone Number

Aliases

Erythrocyte 65 kDa protein antibody; HSAN2 antibody; HSN2 antibody; hWNK1 antibody; KDP antibody; KIAA0344 antibody; Kinase deficient protein antibody; MGC163339 antibody; MGC163341 antibody; p65 antibody; PPP1R167 antibody; PRKWNK1 antibody; Prostate derived sterile 20 like kinase antibody; Protein kinase lysine deficient 1 antibody; Protein kinase lysine-deficient 1 antibody; Protein kinase with no lysine 1 antibody; Protein phosphatase 1, regulatory subunit 167 antibody; PSK antibody; Serine/threonine protein kinase WNK1 1 antibody; Serine/threonine protein kinase WNK1 2 antibody; Serine/threonine protein kinase WNK1 antibody; Serine/threonine-protein kinase WNK1 antibody; With no K antibody; WNK lysine deficient protein kinase 1 antibody; WNK lysine deficient protein kinase 1 isoform antibody; WNK1 antibody; WNK1_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9H4A3

Immunogen

Recombinant Human Serine/threonine-protein kinase WNK1 protein (1-207AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

WNK1

Research Areas

Signal transduction