WIPI1 Antibody

Size

100ul

Clone Number

Aliases

ATG 18 antibody; ATG18 antibody; Atg18 protein homolog antibody; ATG18A antibody; FLJ10055 antibody; WD repeat domain phosphoinositide interacting 1 antibody; WD repeat domain phosphoinositide interacting protein 1 antibody; WD repeat domain phosphoinositide-interacting protein 1 antibody; WD40 repeat protein interacting with phosphoinositides of 49 kDa antibody; WD40 repeat protein interacting with phosphoInositides of 49kDa antibody; WIPI 1 alpha antibody; WIPI 1 antibody; WIPI 49 antibody; WIPI 49 kDa antibody; WIPI-1 antibody; wipi1 antibody; WIPI1_HUMAN antibody; WIPI49 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q5MNZ9

Immunogen

Recombinant Human WD repeat domain phosphoinositide-interacting protein 1 protein (187-446AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

Background

Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

WIPI1

Research Areas

Cancer; Metabolism; Signal transduction