WDR77 Monoclonal Antibody

Size

Clone Number

Aliases

2610312E17Rik; Androgen receptor cofactor p44; C79984; HKMT1069; MEP 50; MEP-50; MEP50; MEP50_HUMAN; Methylosome protein 50; MGC2722; Nbla10071; p44; p44/Mep50; RGD1310479; RP11 552M11.3; WD repeat containing protein 77; WD repeat domain 77;

Immunogen Species

Human

UniProt ID

Q9BQA1

Immunogen

Purified recombinant human WDR77 protein fragments expressed in E.coli.

Raised in

Mouse

Species Reactivity

Human,Mouse,Rat

Tested Applications

ELISA,WB,ICC;Recommended dilution:WB:1:500-1:5000,ICC:1:50-1:200

Background

Non-catalytic component of the 20S PRMT5-containing methyltransferase complex,which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones.This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles.Might play a role in transcription regulation.The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4),methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.

Clonality

Monoclonal

Isotype

IgG1

Purification Method

Affinity purified

Conjugate

Non-conjugated

Buffer

Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.

Form

liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

WDR77

Research Areas

Epigenetics and Nuclear Signaling;Signal transduction