WDR77 Antibody

Size

100ul

Clone Number

Aliases

2610312E17Rik antibody; Androgen receptor cofactor p44 antibody; C79984 antibody; HKMT1069 antibody; MEP 50 antibody; MEP-50 antibody; MEP50 antibody; MEP50_HUMAN antibody; Methylosome protein 50 antibody; MGC2722 antibody; Nbla10071 antibody; p44 antibody; p44/Mep50 antibody; RGD1310479 antibody; RP11 552M11.3 antibody; WD repeat containing protein 77 antibody; WD repeat domain 77 antibody; WD repeat-containing protein 77 antibody; WDR77 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9BQA1

Immunogen

Recombinant Human Methylosome protein 50 protein (1-260AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

Background

Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

WDR77

Research Areas

Epigenetics and Nuclear Signaling; Signal transduction