WDFY3 Antibody, HRP conjugated

Size

100ug

Clone Number

Aliases

WDFY3 antibody; KIAA0993 antibody; WD repeat and FYVE domain-containing protein 3 antibody; Autophagy-linked FYVE protein antibody; Alfy antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q8IZQ1

Immunogen

Recombinant Human WD repeat and FYVE domain-containing protein 3 protein (1-100AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Required for selective autophagy (aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies (p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

HRP

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

WDFY3

Research Areas

Cardiovascular