VPS52 Antibody, Biotin conjugated

Size

100ug

Clone Number

Aliases

VPS52 antibody; SACM2LVacuolar protein sorting-associated protein 52 homolog antibody; SAC2 suppressor of actin mutations 2-like protein antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q8N1B4

Immunogen

Recombinant Human Vacuolar protein sorting-associated protein 52 homolog protein (277-377AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Biotin

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

VPS52

Research Areas

Signal transduction