VPS36 Antibody

Size

100ul

Clone Number

Aliases

C13orf9 antibody; CGI 145 antibody; EAP45 antibody; ELL associated protein of 45 kDa antibody; ELL-associated protein of 45 kDa antibody; ESCRT-II complex subunit VPS36 antibody; Vacuolar protein sorting associated protein 36 antibody; Vacuolar protein-sorting-associated protein 36 antibody; Vps36 antibody; VPS36_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q86VN1

Immunogen

Peptide sequence from Human Vacuolar protein-sorting-associated protein 36 protein (87-105AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

VPS36

Research Areas

Cell biology; Signal transduction