vcp Antibody

Size

100ul

Clone Number

Aliases

vcp antibody; cdc48 antibody; si:ch211-113n10.2Transitional endoplasmic reticulum ATPase antibody; TER ATPase antibody; EC 3.6.4.6 antibody; Protein CDC48 antibody; Valosin-containing protein antibody; VCP antibody

Immunogen Species

Zebrafish

UniProt ID

Q7ZU99

Immunogen

Recombinant Zebrafish Transitional endoplasmic reticulum ATPase protein (704-806AA)

Raised in

Rabbit

Species Reactivity

Zebrafish

Tested Applications

ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background

Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites and promotes the recruitment of tp53bp1 at DNA damage sites (By similarity). Enhances cell cycle progression and inhibits apoptosis at low temperatures (PubMed:12914916). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (By similarity). Acts as a negative regulator of type I interferon production by promoting ubiquitination of ddx58/rig-i (By similarity). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

vcp

Research Areas

Neuroscience; Metabolism; Signal transduction