VAV3 Antibody

Size

100ug

Clone Number

Aliases

FLJ40431 antibody; Guanine nucleotide exchange factor VAV3 antibody; Protein vav 3 antibody; Protein vav3 antibody; RGD1565941 antibody; VAV 3 antibody; Vav 3 guanine nucleotide exchange factor antibody; VAV 3 oncogene antibody; VAV 3 protein antibody; VAV-3 antibody; Vav3 antibody; VAV3 oncogene antibody; VAV3 protein antibody; VAV3_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UKW4

Immunogen

Recombinant Human Guanine nucleotide exchange factor VAV3 protein (562-674AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse, Rat

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200

Background

Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

VAV3

Research Areas

Cancer; Signal transduction