UVSSA Antibody

Size

100ug

Clone Number

Aliases

hypothetical protein LOC57654 antibody; K1530_HUMAN antibody; KIAA1530 antibody; Uncharacterized protein KIAA1530 antibody; UV stimulated scaffold protein A antibody; UVSS3 antibody; UVSSA antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q2YD98

Immunogen

Recombinant Human UV-stimulated scaffold protein A protein (143-206AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:200-1:500

Background

Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

UVSSA

Research Areas