ULBP1 Antibody

Size

100ug

Clone Number

Aliases

Alcan beta antibody; ALCAN-beta antibody; N2DL-1 antibody; N2DL1 antibody; N2DL1_HUMAN antibody; NKG2D ligand 1 antibody; NKG2D ligand 1 precursor antibody; NKG2DL1 antibody; RAET1I antibody; Retinoic acid early transcript 1I antibody; UL16 antibody; UL16 binding protein 1 antibody; UL16-binding protein 1 antibody; ULBP1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9BZM6

Immunogen

Recombinant Human UL16-binding protein 1 protein (26-216AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:20-1:200

Background

Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

ULBP1

Research Areas

Immunology