UIMC1 Antibody

Size

100ug

Clone Number

Aliases

BRCA1-A complex subunit RAP80 antibody; Nuclear zinc finger protein RAP80 antibody; OTTHUMP00000161441 antibody; OTTHUMP00000223372 antibody; OTTHUMP00000223374 antibody; RAP80 antibody; Receptor associated protein 80 antibody; Receptor-associated protein 80 antibody; Retinoid X receptor interacting protein 110 antibody; Retinoid x receptor interacting protein antibody; Retinoid X receptor-interacting protein 110 antibody; RIP110 antibody; Rxrip110 antibody; Ubiquitin interaction motif containing 1 antibody; Ubiquitin interaction motif containing protein 1 antibody; Ubiquitin interaction motif-containing protein 1 antibody; UIMC1 antibody; UIMC1_HUMAN antibody; X2HRIP110 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96RL1

Immunogen

Recombinant Human BRCA1-A complex subunit RAP80 protein (161-235AA)

Raised in

Rabbit

Species Reactivity

Human, Rat

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000

Background

Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds \\\'Lys-63\\\'-linked ubiquitin (PubMed:19328070, Ref.36). Plays a central role in the BRCA1-A complex by specifically binding \\\'Lys-63\\\'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes \\\'Lys-63\\\'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than \\\'Lys-63\\\'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48\\\'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

UIMC1

Research Areas

Epigenetics and Nuclear Signaling