UFD1 Antibody

Size

100ul

Clone Number

Aliases

UB fusion protein 1 antibody; Ubiquitin fusion degradation 1 like (yeast) antibody; Ubiquitin fusion degradation 1 like antibody; Ubiquitin fusion degradation protein 1 homolog antibody; UFD1 antibody; UFD1_HUMAN antibody; UFD1L antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q92890

Immunogen

Recombinant Human Ubiquitin recognition factor in ER-associated degradation protein 1 protein (1-307AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

UFD1

Research Areas

Cell biology