UBE2S Antibody

Size

100ul

Clone Number

Aliases

AA409170 antibody; E2 EPF antibody; E2-EPF antibody; E2EPF antibody; EPF5 antibody; MGC101982 antibody; Ube2s antibody; UBE2S_HUMAN antibody; Ubiquitin carrier protein S antibody; Ubiquitin conjugating enzyme E2 24 kD antibody; Ubiquitin conjugating enzyme E2 24 kDa antibody; Ubiquitin conjugating enzyme E2 EPF5 antibody; Ubiquitin conjugating enzyme E2 S antibody; Ubiquitin conjugating enzyme E2S antibody; Ubiquitin protein ligase S antibody; Ubiquitin-conjugating enzyme E2 S antibody; Ubiquitin-conjugating enzyme E2-24 kDa antibody; Ubiquitin-conjugating enzyme E2-EPF5 antibody; Ubiquitin-protein ligase S antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q16763

Immunogen

Recombinant Human Ubiquitin-conjugating enzyme E2 S protein (1-222AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes \\\'Lys-11\\\'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating \\\'Lys-11\\\'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except \\\'Lys-48\\\'-linked polyubiquitination.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

UBE2S

Research Areas

Epigenetics and Nuclear Signaling