UBA6 Antibody

Size

100ul

Clone Number

Aliases

E1-L2 antibody; FLJ10808 antibody; FLJ23367 antibody; Monocyte protein 4 antibody; MOP 4 antibody; MOP-4 antibody; MOP4 antibody; UBA 6 antibody; Uba6 antibody; UBA6 ubiquitin activating enzyme E1 antibody; UBA6_HUMAN antibody; UBE1L2 antibody; Ubiquitin activating enzyme 6 antibody; Ubiquitin activating enzyme E1 like 2 antibody; Ubiquitin activating enzyme E1 like protein 2 antibody; Ubiquitin like modifier activating enzyme 6 antibody; Ubiquitin-activating enzyme 6 antibody; Ubiquitin-activating enzyme E1-like protein 2 antibody; Ubiquitin-like modifier-activating enzyme 6 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

A0AVT1

Immunogen

Recombinant Human Ubiquitin-like modifier-activating enzyme 6 protein (1-260AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

UBA6

Research Areas

Epigenetics and Nuclear Signaling; Cell biology