UBA3 Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes| or E1s| ubiquitin-conjugating enzymes| or E2s| and ubiquitin-protein ligases| or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1| an amyloid beta precursor protein binding protein| to form a heterodimer| and then the enzyme complex activates NEDD8| a ubiquitin-like protein| which regulates cell division| signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human UBA3

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

50930

synonyms

UBA3