UBA3 Antibody

Size

100ul

Clone Number

Aliases

DKFZp566J164 antibody; EC 6.3.2. antibody; hUba3 antibody; MGC22384 antibody; NEDD8 activating enzyme E1 catalytic subunit antibody; NEDD8 activating enzyme E1C antibody; Nedd8 activating enzyme hUba3 antibody; NEDD8-activating enzyme E1 catalytic subunit antibody; NEDD8-activating enzyme E1C antibody; uba3 antibody; UBA3 ubiquitin activating enzyme E1 homolog antibody; UBA3_HUMAN antibody; UBE1C antibody; Ubiquitin activating enzyme 3 antibody; Ubiquitin activating enzyme E1C antibody; Ubiquitin-activating enzyme 3 antibody; Ubiquitin-activating enzyme E1C antibody; Ubiquitin-like modifier-activating enzyme 3 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q8TBC4

Immunogen

Recombinant Human NEDD8-activating enzyme E1 catalytic subunit protein (234-463AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

UBA3

Research Areas

Cell biology