U2AF2 Antibody

Size

100ug

Clone Number

Aliases

hU2AF(65) antibody; hU2AF65 antibody; Splicing factor U2AF 65 kDa subunit antibody; U2 (RNU2) small nuclear RNA auxiliary factor 2 antibody; U2 auxiliary factor 65 kDa subunit antibody; U2 small nuclear ribonucleoprotein auxiliary factor (65kD) antibody; U2 small nuclear RNA auxiliary factor 2 antibody; U2 snRNP auxiliary factor large subunit antibody; U2af2 antibody; U2AF2_HUMAN antibody; U2AF65 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P26368

Immunogen

Recombinant Human Splicing factor U2AF 65 kDa subunit protein (124-246AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background

Necessary for the splicing of pre-mRNA. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

U2AF2

Research Areas

Epigenetics and Nuclear Signaling