TXNIP Antibody

Size

100ug

Clone Number

Aliases

EST01027 antibody; HHCPA78 antibody; THIF antibody; Thioredoxin binding protein 2 antibody; Thioredoxin interacting protein antibody; Thioredoxin-binding protein 2 antibody; Thioredoxin-interacting protein antibody; TXNIP antibody; TXNIP_HUMAN antibody; Upregulated by 1,25 dihydroxyvitamin D 3 antibody; VDUP1 antibody; Vitamin D3 up-regulated protein 1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9H3M7

Immunogen

Recombinant Human Thioredoxin-interacting protein (299-381AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IF; Recommended dilution: IF:1:50-1:200

Background

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

TXNIP

Research Areas

Epigenetics and Nuclear Signaling; Cancer; Cell biology; Metabolism; Signal transduction